My single player Op4 campaign (tentatively titled "Op4: Wrench/Barnacle/Snipe") emphasizes use of just the wrench for most of it, then the grapple, and finally the sniper rifle.
Do people generally hate that? The problem I face is that, for people who love the wrench (like me), it's extremely easy to clear rooms of monsters. For people who hate melee, it will be super difficult.
Just be careful about the difficulty ramp. Warm them up with some headcrabs and breakables first and slowly increase the encounter difficulty instead of dropping the player directly into an arena with several gonomes and bullsquids. Let them become comfortable with it before challenging them, so to speak.
If the enemies have ranged attacks, give the player plenty of cover so they don't end up feeling defenceless (which in turn is experienced as unfair and difficult by the player).
I guess I won't know if it's too difficult until I get it playtested.