I've come to the conclusion that going from Mass Effect 2 to this game was a bad choice.
There was so many things in Mass Effect that I wanted to be in Fallout, mainly the dialogue. It kinda made me skip a lot of it, for some reason. I just got bored too easily.
That being said, I just did my first play through. I sided with the NCR with the help of the boomers and Brotherhood of Steel.
Didn't particularly like the ending, but oh well.
Also, I did that one perk that makes weird stuff happen, whatever it's called. I can't say I ever actually noticed anything weird.
I'm going to play through again. I think being evil in this one will be fun.
ONE LAST THING:
I wanted to be neutral. Apparently playing through with the NCR makes that impossible, because every one you kill gives you good karma. I ended up being very good and it pissed me off.